Login Contact Us
E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2019, Vol 6, Issue 1
Advanced Search
Title
Authors
Keyword
Poll
How do you find the scientific quality of the published articles on our web site?
Original Article
Preventing Nausea and Vomiting Using Ondansetron and Metoclopramide-Phenylephrine in Cesarean Section Using Spinal Anesthesia
Sousan Rasooli1, Farnaz Moslemi1, Morteza Gogazadeh1
1Department of Anesthesia, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran

CJMB 2019; 6: 061-065

Viewed : 58 times
Downloaded : 69 times.

Keywords : Metoclopramide, Ondansetron, Nausea-vomiting, Cesarean section, Spinal anesthesia
Full Text(PDF) | Related Articles
Abstract
Objectives: The present study evaluated the effect of combining 2 drugs, namely, ondansetron and metoclopramide-phenylephrine on intra- and postoperative nausea and vomiting (PONV) in patients who selectively underwent cesarean section (C-section) surgery using spinal anesthesia.

Materials and Methods: This randomized double-blind clinical trial controlled with placebo was conducted on 110 patients with class I and II ASA who underwent C-section with spinal anesthesia. Patients within the age range of 20-30 years were divided into 2 groups including 55 subjects. The first group received 10 mg IV metoclopramide while the second group received 10 and 0.4 mg bolus of the metoclopramide-phenylephrine combination before the spinal anesthesia and after closing the umbilical cord, respectively. Prophylactic phenylephrine was injected after the spinal anesthesia. In addition, the patients were anesthetized using bupivacaine 10 mg plus fentanyl 10 mg. Hemodynamic was monitored every 3 minutes. Further, intraoperative and postoperative complications, nausea and its intensity, cut-off point, sedation score, and epinephrine were recorded.

Results: No significant difference was found regarding demographic characteristics. (P > 0.05). The incidence and severity of nausea and vomiting were significantly lower in metoclopramide-ondansetron group compared to the metoclopramide group (P = 0.033 & P = 0.03, respectively). As regards the phenylephrine infusion, there were no significant differences in blood pressure, heart rate, and ephedrine consumption between the 2 groups. Furthermore, the incidence of other complications like shivering and pruritis was similar in both groups.

Conclusions: Generally, it was revealed that combination therapy with metoclopramide and ondansetron along with prophylaxis of the hypotension with phenylephrine can significantly reduce intra and PONV and its severity in patients undergoing C-section surgery during spinal anesthesia.

 

Cite By, Google Scholar

Google Scholar

Articles by Rasooli S
Articles by Moslemi F
Articles by Gogazadeh M

PubMed

Articles by Sousan Rasooli
Articles by Farnaz Moslemi
Articles by Morteza Gogazadeh

Submit Paper
Online Submission System
CJMB ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Publisher
Aras Part Medical International Press Editors in Chief
Arash Khaki
Editor
Zafer Akan Deputy Editor
Javadi, Leila
Published Article Statistics