|Investigating The Level of Troponin I and its Association with Mortality in Patients with Sepsis, Severe Sepsis and Septic Shock|
|Mahboobeh Darban1, Ali Gohari1, Raheb Ghorbani2, Pourya Sheykhabbasi1|
|1Department of Internal Medicine, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
2Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran
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Keywords : Sepsis, Shock ,Mortality, Troponin
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Objectives: To investigate the level of troponin I and its association with mortality in patients with sepsis, severe sepsis and septic shock.
Materials and Methods: In this clinical trial, 148 patients with sepsis, severe sepsis and septic shock admitted to Semnan’s Kowsar Hospital in 2016-2017 were recruited. Serum troponin levels were measured Serum troponin level was taken during the first 24 hours of admission The second measurement was done in the next 48 hours, which was aiming to increase the likelihood of positive troponin over time; but if the troponin was positive just once, the patient would be in the category of positive troponin. Besides, the patient's prognosis was recorded within 30 days.
Results: 27.7% had troponin levels higher than normal. The mortality rate in patients with normal levels of troponin was 5.6% and in patients with abnormal troponin levels it was 17.1%, which was a significant difference. The age of dead patients was significantly higher than the age of the living patients results showed that among the variables of sex, normal or abnormal level of troponin, age, and type of underlying infection, only age had a significant relationship with the patients’ vital status.
Conclusion: High levels of troponin were not effective in determining the prognosis of patients with sepsis, and only the age factor had a significant relationship with the patients' vital status, while the confirmation or rejection of this hypothesis will need further studies.
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