|The Effect of Hydroalchoholic Extract of Cinnamon Zeylanicum on Oxidative Damages and Biochemical Change in Induced polycystic ovary syndrome|
|Fariba Khodaeifar1, Seyyed Mohammad Bagher Fazljou1, Mohammad Ali Torbati2, Elaheh Oulad Saheb- Madarek3, Amir Afshin Khaki4, Majid Shokoohi4,5, Amir Hossein Dalili6|
|1Department of Traditional medicine, Faculty of traditional med, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Food Science and Technology, Faculty of Nutrition ,Tabriz University of Medical Sciences, Tabriz ,Iran
3Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
6Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords : Oxidative dameges, PCOS, Hormones, Rat
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Objectives:"Polycystic ovary syndrome" (PCOS) known as one of the most usual hormone disturbance in women of childbearing age, according to it, the aim of this research was to investigate the Effect of hydroalchoholic extract of Cinnamon Zeylanicumon oxidative damages and biochemical change in adult rat with PCOS
Materials and Methods: In our experimental research, 32 Wistar female rats were used (n=8/group) including G1: control group, G2: PCOS group without any therapy, G3: rats with PCOS that daily intake the 200 mg/kg/orally of hydroalcoholic extract of Cinnamon Zeylanicumfor 2 weeks, G4: no PCOS which was daily intake the extract of Cinnamon Zeylanicum200mg/kg for 2 weeks. PCOS induced by estradiol valerate with single injection dose (16mg/kg intramuscularly). After 14 days, all of the animals in study groups were anesthetized with ketamine and xylazine, then the blood sample was removed and their plasma was used for checking the blood glucose, insulin, “follicle-stimulating hormone” (FSH), “luteinizing hormone” (LH), estrogen, and testosterone. The ovarian of all animals were removed and fixed for assessment of histological damage.
Results:In the plasma levels of blood glucose, insulin, LH, FSH, and testosterone was observed a significant change between G2 and G1, while in G3 and G4 they were significantly declined compared to G2. In addition, the level of estrogen in plasma was decreased significantly in G2 as compared toG1, while in G2 and G1, it was higher than PCOS group significantly. moreover, the number of follicles reduced in PCOS group, while in the groups treated with Cinnamon Zeylanicum extract increased.
Conclusion:results of present research show that the hydroalcholic extract of Cinnamon Zeylanicumhas a beneficial effect on regulating the plasma levels of “testosterone,estradiol, LH, FSH, FBS, and insulin” in the palliation of PCOS complications.
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