|Effects of Hydroalcoholic Extracts of Cloves (Syzygium aromaticum) on Serum Biomarkers, Antioxidant status and Histopathological Changes of Kidneys in Diabetic Rats|
|Seyd-Hosein Abtahi-Eivari1, Majid Shokoohi2,3, Mohammad Ghorbani1, Hossein hajizadeh4, Hossein Kalarestaghi3, Hamed Shoorei3, Javad Bahrami5, Zohreh Ghoreishi6|
|1Department of Basic Sciences, faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
2Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran
3Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Nutrition, faculty of Nutrition and food sciences, Tabriz University of Medical Sciences, Tabriz, Iran
5Department of Environmental Health Engineering, faculty of Health, Zanjan University of Medical Sciences, Zanjan, Iran
6Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz,Iran
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Keywords : Antioxidant status, Cloves, Diabetes, Lipid profile, Kidney damages
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Objectives:The aim of this study was to evaluate the possible effects of hydroalcoholic Extracts of Cloves (Syzygium aromaticum) on glucose status, lipid profile, and histopathological changes in kidneys of Diabetic Rats.
Materials and Methods :Thirty-two male rat were divided into 4 groups (n=8), including one group as healthy control and three diabetic groups. Diabetes was induced by streptozotocin (50 mg/kg). Diabetic rats were calcified into a diabetic control group (DC), diabetic treated with 4 mg/kg hydroalcoholic extract of Syzygium aromaticum (DSA), DG group treated with 5 mg/kg glibenclamide. After the treatment period, rats’ blood sampling and kept in -70 °C to test blood levels of glucose, insulin, lipid profile, some oxidative stress markers and antioxidant enzymes. And kidney was removed for histological study.
Result:The levels of FBS were significantly lower in the control, DSA, and DG groups than the DC group (p<0.05); while insulin levels were significantly lower in the DC, DSA, and DG groups than the control group (p<0.05); The level of Urea and creatinine in plasma were significantly increased in DC group and significantly reduced in other groups (p<0.05); The serum levels of SOD and GPX were significantly increased in the DSA and DG groups as compared the DC group and also the serum levels of MDA was significantly decreased in the treaputic groups. Syzygium aromaticum showed antioxidant properties and protected the kidneys of the experimented rats from diabetes-induced renal damages.
Conclusion:The results of this study indicated that Syzygium aromaticum may have beneficial effects in diabetes through improving glycemic control and lipid profile and preventing from diabetes-induced kidney damages.
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