|Histone Deacetylase Inhibitor Valproic Acid has a Profound Inhibitory and Apoptotic Effects on Different Cancers|
|Masumeh Sanaei1, Fraidoon Kavoosi1|
|1Research Center for Non-communicable Diseases, Jahrom University of Medical sciences, Jahrom, Iran|
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Keywords : Valproic acid, Molecular mechanism
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Objectives Histone acetylation is determined by a balance between the activities of enzymes that involve in the histone modifications including histone deacetylases (HDACs) and histone acetyltransferases (HATs) which affect gene expression and play a significant role in carcinogens. Valproic acid (VPA) belongsto the histone deacetylase inhibitors (HDACIs) family which inhibits HDACs activity and regulate biological events, such as apoptosis in various cancer. The current review summarizes various pathways by which VPA affects different types of cancers.
Materials and Methods: For this review, an online search of different sources such as ISI, PubMed, and Scopus resulted in finding the articles correlated with mechanisms and pathways of the VPA on different cancers.
Results: Based on these results, VPA may be a suitable agent and a good candidate for cancer treatment with multiple mechanisms of apoptosis induction.
Conclusion: We conclude that VPA can protect against cancer by regulating histone modification and tumor suppressor genes re-activation.
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