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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2019, Vol 6, Issue 1
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Original Article
Effects of Electrocauterization Smoke on Nasal Mucosa in Rat
Hoda Khoshdel Sarkarizi1, Ramin Salimnejad2, Amir hosein Jafarian3, Masoumeh Fani1, Nasim Khajavian4, Esmail Nourmohamadi5, Ghasem Sazegar1
1Department of Anatomical Sciences and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Research laboratory for Embryology and Stem Cells, Department of Anatomical Sciences and Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
3Department of pathology, Ghaem hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Biostatistics and Epidemiology, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran
5Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


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Keywords : Complication, Electrocauterization smoke,Nasal mucosa, Rat
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Abstract

Objectives: Electrocautery unite used for vascular homeostasis. Despite the advantage of electrocautery in surgical interventions, it also has several disadvantages such as pulmonary respiratory disorders, emphysema, bronchitis, and asthma. The present study investigated the effects of electrocauterization smoke on rat nasal mucosa

Materials and Methods:Fifteen Wistar rats divided into 3 groups (n=5) for 3 time phases. Smoke was produced by electrocauterization of an anesthetized rat within the smoke chamber, and smoke was entered to test chamber containing experimental rat. At the end, rats were anesthetized and nasal mucosa dissected under a stereomicroscope. After H&E staining, the samples were impartially evaluated by a pathologist and frequency of complications was compared between different groups. TUNEL technique was done to investigate the apoptosis.

Results:Pathological studies showed complications such as vascular congestion, epithelial vacuolation, acute inflammation, and the presence of necrotic cells. Statistical analysis showed the rate of vascular congestion, acute inflammation, and inflammation in glands in the second and third phases of the study significantly increased compared to the control group and the difference between the experimental groups was only significant when the first phase was compared with the second(p<0.05).The rate of epithelial vacuolation and presence of necrotic cells had no significant increase in comparison to the control group. Numerical density of apoptotic cells significantly increased within the respiratory epithelium and submucosal glands of the experimental rats (p0<0.05).

Conclusion:The results of this study indicated that short-term exposure to electrocauterization smoke has no specific effect, but longer duration of smoke exposure can damage the rat nasal mucosa.

 

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Aras Part Medical International Press Editors in Chief
Arash Khaki
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Zafer Akan Deputy Editor
Javadi, Leila
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