|Effect of Dry Needling on miR-939 and miR-25 Serum Levels in MyofascialPainSyndrome with Shoulder Girdle Myofascial Trigger Points|
|Naghikhani Mehrdad1, Tayefi Nasrabadi Hamid1, Soleimanirad Jafar2, Joghataei Mohammad Taghi3, Arablu Amir Massoud4|
|1Department of Anatomical Science Faculty of Medicine Tabriz University of Medical Sciences Iran
2Stem Cell Research Center, Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3Cellular and Molecular Research Center, Department of Anatomical Science of Iran University of Medical Sciences, Tehran, Iran
4Department of Physical Therapy, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
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Keywords : Dry needling,MicroRNA, MIR-939 ,MiR-25 ,Pain ,MTrPs, Muscle pain
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Objectives:Micro-RNAs (miR) affect the gene expression of the pain and inflammation mediators. Myofascial trigger points (MTrPs) are one of the most common causes of skeletal and muscle pain. In this regard, Dry Needling (DN) has been favored by physiotherapists as an effective method of treatment for MPS. This study aimed to assess the effectiveness of DN on serum concentration of miR-939 ,miR-25 before and after treatment in patients with muscular pain caused by MTrPs in their shoulder girdle muscles.
Materials and Methods: Twenty patients with pain in their shoulders, upper limbs, heads and necks who had 3-5 active MTrPs in their shoulder girdle muscles participated in the study.They were treated in 5 sessions of DN; one session per day every three days for two weeks. Before and after treatment, the pain intensity of patients was measured using Visual Analogue Scale (VAS) , their peripheral blood samples were taken and miR serum concentrations were measured by real-time PCR.
Results: Comparison of pain intensity in patients showed a significant reduction (P<0.05) after treatment.Statistical analysis indicated up regulation of miR-939 and miR-25 with a significant difference (P<0.05) after the treatment vs. before the treatment.
Conclusion: According to the reduction in pain intensity and increased expression of miR-939 and miR-25 serum levels after treatment, it can be concluded that DN is an effective technique for treatment ofMPS in shoulder girdle muscles.
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