|The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients|
|Fahimeh Hosseinzadeh1, Nader Jangi Oskouei2, Saeid Ghavamzadeh3|
|1Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
2Internist, Cardiologist, Urmia University of Medical Sciences, Urmia, Iran
3Department of Nutrition, Food and Beverages Safety Research Center, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
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Keywords : Brain, Heart Failure, Tumor Necrosis Factor-alpha, Natriuretic Peptide,Vitamin D
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Objectives:Vitamin D deficiency is prevalent in heart failure (HF). Anti-inflammatory impacts of vitamin D may affectthe pathogenesis of HF. This study aimed to check out the impact of vitamin D supplementation on echocardiographic and biochemical factors in vitamin D deficient HF patients.
Materials and Methods: Thirty-nine HF patients with25(OH)D ≤ 20 ng/ml participated in a double-blind, randomized and placebo-controlled trial. They belonged to the class III, New York Heart Association (NYHA) classification. 50, 000 IU vitamin D3 (group D+) or placebo (group D-) were prescribed withintwo months.Ejection Fraction (EF %), Tumor Necrosis Factor alpha (TNF-α), B type natriuretic peptide (BNP) and high sensitive C- reactive protein (hs-CRP)were assessed before and after supplementation.
Results: The mean serum level of 25(OH)D incremented markedly in D+ group (P<0.001). The meanincrease of EF% was 5.3±9.03% (P=0.03) and the decrease of TNF-α (-0.09 pg/ml, P<0.001) and BNP (-3.14 ng/ml, P=0.04) were statistically significant inD+group after supplementation. The blood concentration of BNP declined significantly in D+ group in comparison with placebo; however, hs-CRP and TNF-α levels did not differ between the two groups.
Conclusion: The results revealedthat vitamin D could be effective against inflammationand itssupplementation may reduce the severity of HF by improvement in the serum level of BNP and EF%;however, it stands to reason that more clinical trials have to be done to approve the beneficial role of vitamin D in HF patients.
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