|Effects of Dust Micro Particles of Asalouyeh Area (South of Iran) on The Thyroid and Parathyroid Glands in Rat|
|Fereshteh Maleki1, Mostafa Mohammadi2, Habibollah Nazem1, Vahid Keshavarz1, Ali Hosseini3, Alireza Chamkori4, Afshar Bargahi5, Parviz Farzadinia6|
|1Department of Biochemistry, Payame noor University of Taft, Yazd, Iran
2Young researchers and elite club, Bushehr branch, Islamic azad University, Bushehr, Iran
3Department of Marine Biotechnology, Faculty of Marine Science and Technology, Persian Gulf University, Bushehr, Iran
4Department of Biology Development, Faculty of Basic Sciences, Islamic azad University, Kazerun Branch, Kazerun, Iran
5The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
6Department of Biology and Anatomical sciences, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
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Keywords : Dust, air pollution, Asalouyeh, thyroid , parathyroid
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Objective:The aim of this study is to evaluate possible changes in the thyroid and parathyroid glands tissue and functional structures.
Material and Methods: 30 adult female rats were divided into three groups: control, negative control (exposed to dust in the clean area free from oil contaminants) and the treatment group (exposed to dust in the polluted area of Asalouyeh with oil hydrocarbons) after co-cycling. Before grouping, all animals were co-cycled. After 25 days of treatment, changes in pancreatic tissue and serum levels of thyroid and parathyroid hormones were measured. Moreover, the amount of the heavy metals lead, cadmium, arsenic, and mercury in animals’ serum were measured using atomic absorption.
Results: The amount of heavy metals lead, cadmium, arsenic, and mercury showed a significant increase in the serum of animals in the treatment group compared to the negative control group and the control group (P≤0.05). Serum levels of thyroid and parathyroid hormones in the treatment group show a significantly decrease in comparison with control groups. Moreover, histological investigations show relative changes in tissue and functional structures of important thyroid and parathyroid glands tissues.
Conclusion: Dust of polluted air of Asalouyeh has relative toxicity effects on thyroid and parathyroid tissues and their hormones.
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