|Case Report: A Novel Therapy For The Treatment of Malefactor Infertility Due to Non-obstructive Azoospermia|
|Mohammed Iqbal Cassim1, Tasneem Mohamed1|
|1Bio ART Fertility Centre, Rosebank, South Africa|
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Keywords : Non-obstructive Azoospermia, Infertilty, Stem cell therapy
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A case report on a novel treatment protocol using autologous stem cells, derived from adipose tissue, for the treatment of non-obstructive azoospermia. In this case report the male partner after undergoing this treatment had restored spermiogenesis and the couple underwent IVF therapy. Fertilization was successful and good quality embryos were produced.
Introduction: The advent of assisted reproductive technology has afforded many previously "infertile" couples the gift to produce offspring. Through various techniques like ovulation induction, artificial insemination, In-Vitro Fertilization (IVF) and Intra-cytoplasmic sperm injection (ICSI), many pathologies responsible for infertility have been overcome.However, male factor infertility due to primary non-obstructive azoospermia remains a challenge for the couple, as well as for the attending infertility specialist. Azoospermia is the total absence of sperm in the ejaculate. It may be obstructive or non-obstructive. In the obstructive type, sperm may be found in the testes itself but not in the ejaculate due either congenital or acquired obstruction of the ejaculatory duct. Non-obstructive azoospermia of the other hand is due to an inability of the testes to produce sperm either due to the fact that there is inadequate central stimulation of the testes or an abnormality within the testes itself whereby the testis is not capable of spermiogenesis. To date, various treatments using stem cells are being explored with variable success to treat azoospermia and enable the "infertile" male to father a biological child. We report on a novel treatment protocol using adult adipose derived stem cells to restore spermatogenesis leading to the in-vitro production of transfer grade embryos.
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