Spinal Cord Injury‚ Oxidative Stress, and Antioxidants: Impact on Male Fertility

Soheila Bani; Parviz Shahabi; Jalal Abdolalizadeh; Iraj Lotfinia; Amir Vahedi; Meysam Ghorbani; Amir shakouri

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Jul 2019, Vol 6, Issue 3

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Spinal Cord Injury‚ Oxidative Stress, and Antioxidants: Impact on Male Fertility
Soheila Bani¹, Parviz Shahabi², Jalal Abdolalizadeh³, Iraj Lotfinia⁴, Amir Vahedi⁵, Meysam Ghorbani², Amir shakouri⁶
¹Neuroscience Research Center, Nursing and midwifery faculty, Tabriz University of Medical Sciences, Iran ²Neuroscience Research Center, Medical Faculty, Tabriz University of Medical Sciences, Iran ³Drug Applied Research Center, Parmedicine Faculty, Tabriz University of Medical Sciences, Tabriz, Iran ⁴Neuroscience Research Center, Medical Faculty, Tabriz University of Medical Sciences, Iran ⁵Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran ⁶Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
CJMB 2019; 6: 253-266 Viewed : 3230 times Downloaded : 2400 times. Keywords : Spinal cord injury, Oxidative stress, Antioxidants, Men fertility
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Abstract

Objectives: Spinal cord injury (SCI) often occurs in young adult men. Factors such as erectile and ejaculation dysfunction and abnormal anomalies may contribute to the incidence of infertility. In healthy men, there is a balance between reactive oxygen species (ROS) and antioxidant scavenging systems and antioxidants have a positive impact on male fertility. Therefore, the present study examined the findings of different review studies on the role of oxidative stress (OS) and antioxidants in reducing the sperm function and treating the sperm components, respectively. Materials and Methods: The relevant keywords were used to search for related articles in different databases such as Medline, PubMed, ISI, Scopus, and Google Scholar, which resulted in retrieving 28 articles about OS, antioxidants, DNA damage, apoptosis, and sperm parameters. Results: Based on the findings of previous studies, antioxidant supplementation improved the number, motility, morphology, and the DNA integrity of the sperm. In addition, the combination of several antioxidants was found to perform better compared to using only one antioxidant. Conclusions: In general, the heightened levels of uncontrolled OS is modified through the antioxidant supplements or their combination. Therefore, antioxidant supplementation can be considered in the treatment of infertile men.