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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2019, Vol 6, Issue 1
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Review
Spinal Cord Injury‚ Oxidative Stress and Antioxidants: Impact on Male Fertility
Soheila Bani1, Iraj Lotfinia1, Parviz Shahabi2, Jalal Abdolalizadeh3, Amir Vahedi4, Meyssam Ghorbani2, Amir shakouri3
1Research Center of Neuroscience, Tabriz University of Medical Sciences
2Department of Physiology, Medical faculty, Tabriz University of Medical Sciences
3Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Pathology , Tabriz University of Medical Sciences, Tabriz, Iran


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Keywords : Spinal Cord Injury, Oxidative stress,antioxidants, Men fertility
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Abstract

Objectives:Spinal cord injury (SCI) occurs most often in young men. Infertility is secondary to multiple events such as erectile dysfunction, anejaculation, seminal abnormalities.  In healthy men, a balance exists between concentrations of reactive oxygen species (ROS) and antioxidant scavenging systems. Antioxidants generally have a favorable effect on male fertility. We present a review of the literature describing the role of oxidative stress on decreased sperm function, as well as the role of antioxidants in the treatment of semen parameters.

Methods: Relevant key words were used to search in different databases such as Medline, PubMed, ISI, Scopus and Google scholar. We found 28 related articles about Oxidative stress, antioxidants, DNA damage,apoptosis and sperm parameters.

Results:In most of the studies, antioxidant supplementation improved the number, motility, morphology and sometimes DNA integrity of sperm. The combination of several antioxidants acts better than just one antioxidant.

Conclusion: The heightened levels of uncontrolled oxidative stress is correctedby the antioxidant supplements or combination of them. So it should be considered in treatment methods in these patients.

 

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Articles by Bani S
Articles by Lotfinia I
Articles by Shahabi P
Articles by Abdolalizadeh J
Articles by Vahedi A
Articles by Ghorbani M
Articles by Shakouri A

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Articles by Soheila Bani
Articles by Iraj Lotfinia
Articles by Parviz Shahabi
Articles by Amir Vahedi
Articles by Meyssam Ghorbani
Articles by Amir shakouri

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Aras Part Medical International Press Editors in Chief
Arash Khaki
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Zafer Akan Deputy Editor
Javadi, Leila
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