|Spinal Cord Injury‚ Oxidative Stress and Antioxidants: Impact on Male Fertility|
|Soheila Bani1, Iraj Lotfinia1, Parviz Shahabi2, Jalal Abdolalizadeh3, Amir Vahedi4, Meyssam Ghorbani2, Amir shakouri3|
|1Research Center of Neuroscience, Tabriz University of Medical Sciences
2Department of Physiology, Medical faculty, Tabriz University of Medical Sciences
3Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Pathology , Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords : Spinal Cord Injury, Oxidative stress,antioxidants, Men fertility
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Objectives:Spinal cord injury (SCI) occurs most often in young men. Infertility is secondary to multiple events such as erectile dysfunction, anejaculation, seminal abnormalities. In healthy men, a balance exists between concentrations of reactive oxygen species (ROS) and antioxidant scavenging systems. Antioxidants generally have a favorable effect on male fertility. We present a review of the literature describing the role of oxidative stress on decreased sperm function, as well as the role of antioxidants in the treatment of semen parameters.
Methods: Relevant key words were used to search in different databases such as Medline, PubMed, ISI, Scopus and Google scholar. We found 28 related articles about Oxidative stress, antioxidants, DNA damage,apoptosis and sperm parameters.
Results:In most of the studies, antioxidant supplementation improved the number, motility, morphology and sometimes DNA integrity of sperm. The combination of several antioxidants acts better than just one antioxidant.
Conclusion: The heightened levels of uncontrolled oxidative stress is correctedby the antioxidant supplements or combination of them. So it should be considered in treatment methods in these patients.
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