|A Meta-Analysis of the Efficacy of Panax Ginseng on Menopausal Women"s Sexual Function|
|Zahra Ghorbani1, Mojgan Mirghafourvand2|
|1Students' Research Committee, Midwifery Department, Tabriz University of Medical Sciences, Iran
2Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords : Menopause, Panax ginseng,Quality of Life, Sexuality
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Objectives: With an increase in life expectancy, the aging population is growing. This study was designed to evaluate the efficacy and adverse events of ginseng that can be used as an herbal medicine in women with sexual dysfunction.
Material and Methods: We searched Cochrane Library, MEDLINE, Web of Science, Embase, Scopus, ProQuest, Google scholar and Persian databases without a time limitation until May 2018 and examined all RCTs that compared the effect of different types of ginseng compared to placebo controls on sexual function of menopausal women. The Cochrane risk of bias tool was used for assessing the methodological quality of included studies. The heterogeneity was determined by using the I2 index. Standardized Mean Difference was used instead of Mean Differences and random effect reported instead of fixed effect in meta-analysis.
Results: The eligibility criteria were found in five RCTs; all included studies were placebo-controlled. Two trials had parallel design and three studies used Cross-Over design. Four trials indicated that ginseng significantly improved sexual function; although, didn’t report any treatment effect compared to placebo. Based on the results of meta-analysis from five studies (531women), there was no statistically significant effect of Ginseng on FSD compared with placebo (SMD: 0.26; 95% CI: -0.26 to 0.76). Although there was considerable heterogeneity among studies ( = 81%; p < 0.0001). All included studies assessed adverse events but three RCTs reported them but there was no significant difference between placebo and Ginseng groups.
Conclusions: The evidence regarding ginseng as a therapeutic agent for sexual dysfunction is unjustifiable. Rigorous studies seem warranted.
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