|Effects of Dehydroepiandrosterone (DHEA) on Response of Ovarian Stimulation in IVF Cycle in Infertile Women with Diminished Ovarian Reserve: Before and After Clinical Trials|
|MarziehZamaniyan1,2, BaharFarshidfar3, Sepideh Peyvandi1, Hamed Jafarpour4, Robabeh Taheripanah5, Siavash Moradi6, Mojtaba Ghorbani7|
|1Infertility Center, Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran
2Diabetes Research Center, Mazandaran university of Medical Sciences, Sari, Iran
3Student Research Committee, College of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4Medical Student, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5Infertility and Reproductive Health Research Center, ShahidBeheshti University of Medical Sciences, Tehran, Iran
6Community medicine specialist, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran
7Department of Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
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Keywords : Anti-Mullerian Hormone,Dehydroepiandrosterone, Ovarian Reserve, Infertility, Female
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Objectives: One of the best therapies in women with diminished ovarian reserve (DOR), is the use of dihydroepiandrosterone (DHEA) before starting in vitro fertilization (IVF) cycles to increase ovarian reserve. In this study, we aimed to compare the effect of DHEA on women with DOR below and above 35 years old and to see if it"s useful at an earlier age.
Materials and Methods: This is a clinical trial study performed on 35 infertile women with DOR who referred to Imam Khomeini Hospital in Sari in 2017. The intervention was for six weeks, DHEA tablets were used before the start of the ICSI-ET cycle. Antral follicular counts (AFC) and serum AMH levels were measuredbefore and after the intervention and then ICSI was performed.Changes in AMH levels and AFC, number and quality of ovum and embryos and pregnancy, and implantation and abortion rates were measured.
Results: The mean AMH levels (P=0.02) and AFC (p<0.001) after DHEA consumption were significantly different from those prior to administration of DHEA, and the increase in the AFC was more significant in the age group under 35 (p=0.03). Also, these changes were more significant in Body mass less than 25 kg / m2 (P=0.04).
Conclusions: It can be concluded that probably the supplementation of DHEA in women with insufficient ovarian capacity improves IVF prognosis and other parameters including Antral follicular counts and AMH especially in women under 35. Studies have shown that the probability of pregnancy occurrence in women was lower with increased BMI.
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