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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Apr 2020, Vol 7, Issue 2
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Short Communication
The Effect of Artificial Sweetener "Cipla" on Liver Function in Diabetic Male Rats
Ramin Ghasemi1, Jafar Rahmani Kahnamooi1
1Department of Clinical Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran

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Keywords : Cipla, Sucralose, Serum biochemical parameters, Rat, Liver function
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Objectives: Sucralose is an artificial sweetener derived from sucrose, which is 600 times sweeter than sugar and produce low calories. Cipla is a commercial sweetener, which has sucralose and other various constituents. The aim of current study was to investigate the effects of Cipla on some biochemical factors of rats.

Materials and Methods: The study was done on 24 male rats, which was randomly distribute in 4 groups of healthy control, diabetics control, treatment healthy and diabetics treatment. Healthy and diabetic control groups was fed with base diet.  Sucralose was gavage in healthy and diabetics treatment groups 15 mg/Kg daily for a month. Streptozotocin was administered intra peritoneal 65 mg/Kg one dose to induce diabetes. At the end of the study Albumin, bilirubin, total protein, ALT, AST, and ALP of serum was evaluated and results were analyzed by SPSS ver 22. 

Results: Results of study was indicated that the total protein of serum, albumin, and bilirubin, ALT, AST and ALP was not different statistically in different groups (p>0.05).

Conclusion: Results indicated that the Cipla as a sweetener has not any side effects and there was no negative effects on liver function of rat.


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