|Effect of Fish and Flaxseed Oil Supplementation on Isoprenaline-Induced Myocardial Infarction In Rats: Inhibition of Mitochondrial Permeability Transition Pore Opening|
|Seyd Hosein Abtahi Ivary1, Najme Jajarmy1, Mehedi Karimi Shahri1, Majid Shokoohi3, Hamed Shoorei3, Abbas Ebadi2, Maryam Moghimian1, Faraz Sigaroodi3|
|1Department of Basic Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
2Department of Emergency Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords : Isopopernaline, Myocardial Infarction, Fish oil, Flaxseed oil, Cardioprotection
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Objectives: Dietary n-3 polyunsaturated fatty acids (PUFA) havepositive effects on the heart. In this present study, effects of pretreatment with fish oil (FO) and flaxseed oil (FLO) on rat's heart associated with the isoprenaline (ISO)-induced myocardial injury have been investigated.
Materials and Methods: Four groups (10male Wistar rats/each group), including control, ISO in which acute myocardial ischemiainrats induced by isoprenaline, FO + ISO in which rats pretreatment with fish oil orally for 4 weeks, and FLO + ISO in which rats pretreatment with fish oil and flaxseed oil orally for 4 weeks, were used. At the end of the study, histopathological examinations of cardiac tissues and serum activity of creatine kinase-MB (CK-MB) were assessed. Moreover, Mitochondria were isolated to examine mitochondrial swelling.
Results: Isoprenaline administration significantly increased the serum CK-MB activity compared to control group. Also, in more than 70% of rats in ISO group, severe muscular damage to the heart observed. In FO + ISO group, a remarkable decrease in the intensity of heart tissue destruction and in serum levels of CKMB in comparison with ISO group was observed. In FLO + ISO group, there was no a significant decrease in the serum level ofCKMB compared to ISO group.
Conclusion: Pretreatment with flaxseed oil significantly suppressed the intensity of heart tissue destruction as compared to the myocardial ischemic group. Fish oil and flaxseed oil led to decreasing CaCl2-induced swelling in the mitochondria. Our suggestion is that fish and flaxseed oils through inhibiting the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) could lead toprotecting against ischemia/reperfusion injury.
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