|Protective Effect of Grape Seed Extract on Dexamethason-induced Testicular Toxicity in Mice|
|Mohamadpour Masoomeh1, Mollajani Raheleh2, Sarabandi Farhad3, Hosseini Fatemeh 4, Mohsenkia Maryam2, Erfanizaeh Mahboubeh 4, Soleimani Ali5, Kargar Elias4, Mosallaei Halle1, Yavarahmadi Mohammadhosein6|
|1Neuroscience Research Centre, Iran University of Medical Sciences, Tehran , Iran
2Institute for Cognitive Science Studies, Tehran,Iran
3Islamic Azad University Tehran Medical Branch ,Tehran, Iran
4Department of Anatomy ,Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Medical University of Dezful, Master of management Dezful, Iran
6Baqiatallah University of Medical Science, Student Research Center ,Tehran, Iran
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Keywords : Testosterone, Follicle Stimulating Hormone, Luteinizing hormone, Dexamethasone, Grape Seed Extract
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Objective: Protracted and repeated exposure to glucocorticoid such as dexamethason(Dex) may lead to reproductive dysfunction .It is a critical cause of male infertility. Grape Seed Extract (GSE) is an active fraction of as a rich source of flavonoids and phenolic procyanidins used in traditional Chinese medicine. The purpose of this research was determination the effect of GSE on testis and Testosterone, follicle stimulating hormone and luteinizing hormone in mice with establishing dexamethason.
Materials and Methods: Twenty-one adult male Balb/c mice were divided into three groups:1.Control, 2. (Dex) (7 mg/kg/day i.p) and 3. Dex+GSE (100 mg/kg/day dissolved in 0.5 mL of olive oil).All of the animals in control,Dex and Dex+GSE groups were sacrificed after 35 days. Testosterone, FSH and LH levels, spontaneous acrosomal reaction and testis stereological structure were evaluated.
Results: Significant changes in the normal range of testosterone, FSH, LH serum levels, spontaneous acrosomal reaction and number of Sertoli cells, Leydig cells, spermatogonia, spermatocytes and spermatids in Dex group compared to the control rats. These parameters changed to a less extent in Dex+GSE animals compared to the Dex rats.
Conclusion: Our findings propose that GSE might have curative potential on the reproductive system function and its impairment. It’s regulated by Dex and reproductive-related hormones.
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