|Zinc Level in Non-Cirrhotic Chronic Liver Disease and Cirrhosis: A Brief Report|
|Koroush Ghanadi1,2, Afshin Hasanvand3|
|1Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
3Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
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Keywords : cirrhosis, ascites, hepatic encephalopathy, zinc, diuretics
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Objectives: In this report we intend to evaluate zinc serum level in cirrhotic patients (with or without encephalopathy) and patients with non-cirrhotic chronic liver disease.
Materials and methods: In the current analytic cross-sectional study, 75 patients were studied including 25 non-cirrhotic patients with chronic liver disease, 25 patients with liver cirrhosis and 25 cirrhotic patients with hepatic encephalopathy. Then the serum zinc level of their blood samples were measured by spectrophotometry.
Results: The average of zinc level was lower in those who consumed diuretics(p<0.0001). The average of zinc level was lower in patients with ascites significantly (p<0.0001). The average of zinc level concentration was lower in patients with hepatic encephalopathy than patients without encephalopathy and non-cirrhotic chronic liver disease patients. Generally the average of zinc in cirrhotic patients is lower than non-cirrhotic patients and in the group of child A is higher than child B (p= 0.025) and child C (p=0.003).
Conclusion: In overall, the serum level of zinc in patients with cirrhosisis lower than non-cirrhotic patients and its level is lower in diuretics consumers. The reduction of zinc in these patients may be due to less consumption of meat compounds as a rich source of zinc and also the consumption of diuretics that causes increased urinary excretion of zinc.
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