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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2018, Vol 5, Issue 3
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Original Article
Comparing The Efficacy of Surfactant Administration By Laryngeal Mask Airway (LMA) and Endotracheal Intubation in Neonatal Respiratory Distress Syndrome
Mostafa Gharehbaghi Manizheh1, Jabbari Moghaddam Yalda2, Radfar Reza2
1Women’s reproductive health research center-Tabriz University of Medical Sciences. Iran
2Department of Otolaryngology Tabriz University of Medical Sciences,Tabriz, Iran

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Keywords : Endotracheal intubation,Laryngeal mask,Respiratory distress syndrome ,Surfactant administration
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Objective: This study aimed to compare the efficacy of surfactant administration by laryngeal mask airway (LMA) and endotracheal intubation in management of respiratory distress syndrome (RDS) in preterm infants.

Material and Methods: In a prospective interventional study in Al-Zahra Hospital"s NICU, 50 premature infants with gestation age of 33-37 weeks and birth weight of 1800 grams or more that needed surfactant replacement therapy for RDS were randomly allocated in two groups. Twenty five neonates in ETT group received surfactant by endotracheal intubation and the laryngeal mask airway (LMA) were used as a delivery conduct for the administration of surfactant in 25 neonates (LMA group).

Results: The mean gestation age in LMA group was 32.88±1.32 and it was 33.76±2.12weeks in ETT group, p= 0.15.The mean RDS score was not statistically different between two groups, 7.68 ±0.80vs. 7.24 ±1.17, p=0.79. Mechanical ventilation was needed for one neonate in LMA group and 3 infants in ETT group, p=0.16. After surfactant administration, the mean FiO2 requirements to maintain oxygen saturation between 88-92% showed statistically significant decrease in both groups. Needed FiO2 were 0.60±0.12 and 0.57±0.12 before surfactant therapy and decreased to 0.42±0.15 and 0.36±0.10 after surfactant administration in LMA and ETT groups respectively, p<0.001.No choking or vomiting occurred during surfactant therapy in either group.

Conclusion: Based on our findings, the LMA may be a safe and effective alternative way for surfactant administration in late preterm infants. Future multicenter studies recommended for determining safety and efficacy of LMA in preterm infants.


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