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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2018, Vol 5, Issue 1
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Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology
Forough Alemi Serej1, Mohammad Pourhassan-Moghaddam2, Mohammad Ebrahimi Kalan3, Ahmad Mehdipour4, Zeynab Aliyari Serej5, Abbas Ebrahimi-Kalan6
1Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3Epidemiology Department, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida, USA
4Tissue Engineering Department, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
5Applied Cell Sciences Department, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
6Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
7Department of Neurosciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

CJMB 2018; 5: 007-013

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Keywords : mTOR, Molecular targeting, Nanotechnology, Cancer
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Abstract
Mammalian target of rapamycin (mTOR), as an axial mediator of multiple cell growth pathways, is in connection with several other proteins that are involved in the regulation of homeostasis in the cell function. mTOR"s signaling pathway participates in and integrates a variety of environmental cues to control cancer cell and normal tissue development. mTOR and its inhibitors including the rapamycin analogues are attractive therapeutic indication to clinical trials for treating various types of cancers, with or without inhibitors of other signaling pathways. Despite the promising results in cancer treatment, low water solubility of rapamycin is shown to decrease its therapeutic efficacy. To reach an acceptable level of efficacy, high distribution and accepted dispersing of utilized drugs in control of mTOR signaling pathway, nanomaterials-based drug delivery can play an important role. Evaluation of the mechanisms and therapeutic effects of nanoparticle-based mTOR modulation can be useful in developing safe strategies in treatment of cancer. Regarding the clinical importance of mTOR deregulation in human diseases, hereby, we address the recent progress in the field of nanoparticle-based mTOR targeted therapy.
 

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Aras Part Medical International Press Editors in Chief
Arash Khaki
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Zafer Akan Deputy Editor
Javadi, Leila
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