|Effects of Echinacea purpurae Extract on Sperm Characteristics and Hematology Following Testicular Ischemia/Reperfusion (I/R) Injury In Rat|
|Sadegh Motamedi1, Ahmad Asghari1, Alireza Jahandideh1, Gholamreza Abedi1, Pejman Mortazavi2|
|1Department of Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran
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Keywords : Echinacea purpurae, Ischemia/reperfusion, Testis, Rat
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Objective: The aim of the present study was to investigate effect of Echinacea purpurae extract on sperm characteristics following testicular ischemia/reperfusion (I/R) injury in rat.
Materials and Methods: To evaluate this hypothesis, 30 adult rats were randomly divided into five groups: sham operations, I/R group and three groups of treatment with Echinacea purpurae extract (25, 50 and 100 mg/kg). To achieve testicular I/R, 2 hours torsion (720°) of spermatic cord and 24 hours reperfusion of the tests were performed. Treatment was received three different doses of Echinacea purpurae extract intraperitoneal, 1 hour after ischemia. Then, the sperm count, motility and mobility were determined.
Results: There was significant increase in sperm count, motility and mobility in treatment groups compared to I/R group (P<0.05). Treatment with Echinacea purpurae extract (25, 50 and 100 mg/kg) significantly attenuated adverse the effect of testicular IR on sperm mortality compared to the control group (P<0.05). No significant difference was observed in hemograms.
Conclusion: These results confirmed beneficial effect of Echinacea purpurae extract on sperm characteristics after testicular I/R injury in rats.