|Evaluation of Diagnostic Threshold of Amylase and Lipase Enzymes in Diagnosis of Acute Pancreatitis and Their Sensitivity and Specificity|
|Younes Azari Amghani1, Babak Abri Aghdam1|
|1Department of Surgery, Tabriz Branch, Islamic Azad University, Tabriz, Iran|
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Keywords : Pancreatitis, Amylase, Lipase; Cut off, Sensitivity, Specificity
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Objectives: Every sudden and non-traumatic disorder with a major clinical manifestation in the abdomen is considered as an acute abdomen and requires urgent surgery, considering the fact that it is a cause of acute pancreatitis, which is usually associated with increased blood amylase and lipase. Therefore, the diagnostic value of amylase, lipase enzymes and their sensitivity, specificity, with their positive and negative predictive value in the diagnosis of acute pancreatitis evaluated.
Materials and Methods: This descriptive-analytical study examined 244 patients who referred to the Imam Reza and Sina Hospitals of Tabriz. The diagnostic value of two 110 and 550 thresholds (IU/L) for amylase, and 80 and 400 thresholds (IU/L) for lipase were studied.
Results: The results showed that 142 (58.2%) of patients were female. The age mean was 57.97 ± 21.22 years old. Eighty one patients (33.2%) had acute pancreatitis. At 110 (IU/L) cuttoff the sensitivity, specificity, positive predictive value, and negative predictive value of amylase enzyme were 0.762 , 0.407, 0.736 and 0.988, (IU/L) and 550 (IU/L) cutoff, 0.598, 0.943, 0.876 and 0.77, respectively. In the case of lipase, in cut offs=80 (IU/L) and 400(IU/L), the sensitivity=0.84 and 0.519, the specificity= 0.552 and 0.847, positive predictive value= 0.482 and 0.627, negative predictive value= 0.874 and 0.87.
Conclusion: The results showed that as the detection threshold is increased, the specificity of tests is increased, but the sensitivity decreased. Also, studying the level of lipase and amylase enzymes can help in the diagnosis of acute pancreatitis.
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