|Maternal KIR and Parental HLA-C Genes Relationship with Risk of Recurrent Spontaneous Abortion: A Regional Study in Lorestan Province of Iran|
|Soheila Akbari1, Seyyed Amir Yasin Ahmadi2, Farhad Shahsavar3|
|1Department of Obstetrics and Gynecology, Lorestan University of Medical Sciences, Khorramabad, Iran
2Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
3Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran
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Keywords : Recurrent spontaneous abortion, KIR, HLA-C
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Objectives: One of the most important cells playing role in fetomaternal immune tolerance are natural killer cells (NKs). This immune tolerance is induced through interaction of fetal human leucocyte antigens (HLA) and maternal killer-cell immunoglobulin-like receptors (KIR). Hence, we intended to investigate maternalKIR, parental HLA-C, and maternal-paternal KIR+HLA-C combinations with risk of RSA.
Materials and Methods: The present regional study in Lorestan province of Iran has been conducted as case-control on 200 couples. Polymerase chain reaction with specific sequences of primers (PCR-SSP) assay has been used in order to detect genes.
Results: A significant correlation was found for maternal KIR2DS1 in combination with paternal HLA-C2(P=0.0089; OR=2.25). As well a significant relation was found for maternal C1C2 in combination paternal C1 or C2 (P=0.0289; OR=2.25). No significant relation was found for KIR genes alone.
Conclusion: Our study showed a significant relation for maternal KIR2DS1 in combination with paternal HLA-C2 as a risk factor in our region. Investigations of this combination for success rate of assisted reproduction, for first trimester abortions occurring after implantation and early placentation, for stillbirth groups, and for successful and unsuccessful pregnancies of malformed embryos and fetuses is suggested.
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