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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2019, Vol 6, Issue 3
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Original Article
The Effect of Low-dose Ketamine on Prevention of Hypotension Due to Positioning after Induction of General Anesthesia in Lumbar Disc Surgery
Masoud Parish1, Fariba Nikan1, Mohammad Shimia2, Isaa Eslami1, Hojjat Pourfathi1
1Tabriz University of Medical Sciences, Anesthesiology, East Azarbijan, Islamic Republic Of Iran
2Tabriz University of Medical Sciences, Neurosurgery, East Azarbijan,Islamic Republic Of Iran

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Keywords : Ketamine, Hemodynamic changes, Lumbar disc surgery, Repositioning
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Objectives: This study investigate the effect of low-dose ketamine on prevention of hypotension due to positioning after induction of general anesthesia in lumbar disc surgery.

Material and methods: This double-blind clinical trial was performed during three months period in 2016. A random sample of 84 patients with ASA class I were enrolled to the study, and the impact of ketamine on prevention of hypotention due to repositioning were studied. After induction of anesthesia and intubation, ketamine 0.5 mg per kg of body weight in intervention group and, Normal Saline solution in control group with equal volumes were injected. Patients repositioned in similar method to prone position after peak of ketamine (after 1.5 minute), and then systolic, diastolic and mean of blood pressure as a baseline, once before intubation, one minute after intubation, before repositioning, immediately after repositioning the patient from supine to prone position, and then every 2 minutes until ten minutes after repositioning, was measured.

Results: There was significant difference in mean (SD) of systolic pressure and mean of blood pressure in one, second and fourth minute after repositioning, as systolic pressure and mean of blood pressure in ketamine group was higher than control group. The changes of blood pressure in ketamine group after repositioning was least amount.

Conclusion: Ketamine can increase blood pressure, especially systolic pressure of patients.


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