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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2018, Vol 5, Issue 4
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Original Article
Vitamin D Deficiency May be a Modifiable Risk Factor in Woman with Endometriosis
MarziehDerakhshan- Horeh1,2, Maryam Derakhshan3, PegahHedayat3, Maryam Shiasi1, Erfan Sadeghi4
1Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran
2Gynecology and andrology center, Khanevadeh Hospital, Esfahan, Iran
3Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
4Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran

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Keywords : Vitamin D deficiency, Endometriosis, Calcium intake
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Objective: This study examined to determine the levels of 25(OH) D in endometriosis patients and to clarify the association between the endometriosis and intake of calcium and vitamin D dietary.

Material and methods: A total of 200 women with endometriosisas endometriosis group and 154 healthy women(control group) of reproductive age were includedin this study.The plasma detection of 25(OH) D (vitamin D3) was measured by the high pressure liquid chromatography method inendometriosis and control(healthy) group. Participants in two groups were asked about intake of calcium dietary and vitamin D.

Results: Our result showed the association between deficiency of 25(OH) D level and endometriosis risk (OR=29.4, P<0.001). Also, the intake of dietary calcium was inversely associated with recurrence of endometriosis. However, this association was not observed between vitamin D intake and endometriosis.

Conclusions: Our results showed that the decreased level of VD is associated with the endometriosis risk. Accordingly, the authors validate that vitamin D deficiency may have an emergence and predispose factor of endometriosis; Also a decreased risk of endometriosis with increasing Ca intake was observed.Therefore, using of Ca as dietary supplementation may be useful in the managing of endometriosis patients.


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Aras Part Medical International Press Editors in Chief
Arash Khaki
Zafer Akan Deputy Editor
Javadi, Leila
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