Login Contact Us
E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2018, Vol 5, Issue 1
Advanced Search
Title
Authors
Keyword
Poll
How do you find the scientific quality of the published articles on our web site?
Original Article
Estimating The Risk For Chromosomal Abnormalities and Heteromorphic Variants in Azoospermic and Severe Oligozoospermic Men
Zakiye Nadeali1, Peyman Salehi2, Marzieh Derakhshan-Horeh3, Erfan Sadeghi4,5, Amin Izaditabar1, Mansoor Salehi1,6, Majid Hosseinzadeh1,7
1Medical Genetics Laboratory, Alzahra University Hospital, Isfahan, Iran
2Shahid Beheshti Infertility Center, Isfahan, Iran
3Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
5Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
6Department of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
7Department of Medical Genetics, School of Medicine, Tehran University of Medical Science, Tehran, Iran


Viewed : 94 times
Downloaded : times.

Keywords : Male infertility, Chromosomal abnormalities, Heteromorphic variants, Parental consanguinity, Family history
| Related Articles
Abstract
Objectives: A reasonable number of male infertility cases are related to genetic factors. Considering the high prevalence of chromosomal abnormalities related to male infertility, this study investigated the association of the chromosomal aberrations and chromosome variants with hormonal levels, positive family history, parental consanguinity and a specific life style. We also aimed to find a predictive factor to estimating the risk of the presence of an abnormal karyotype in the azoospermic and especially sever oligozoospermic men.

Materials and methods: A total of 230 infertile men and 50 healthy controls enrolled in the study for the cytogenetic evaluation. Data on patients" characteristics was gathered, accurately.

Results: Among aforementioned factors, only LH>12 IU/l raised the chance of detecting a chromosomal (P<0.05). The results also showed a higher level of FSH and parental consanguinity and positive family history of infertility in infertile men compared with the control group (P<0.05). The incidence of chromosome abnormalities and chromosomal variants were 15.2% and 10.9%, respectively. The investigated variables revealed no association with the prevalence of chromosomal heteromorphic variants.

Conclusion: This study suggests positive family history of infertility, parental consanguineous marriages and high levels of FSH as strong determinants or risk factors for male infertility. Nonetheless, the presence of these patient characteristics did not prove to have a direct correlation with chromosomal abnormalities in male infertility. Among the various possible risk factors studied, an elevated gonadotropin level provides a better risk assessment for occurring chromosomal abnormality in infertile men.

 

Cite By, Google Scholar

Google Scholar

Articles by Nadeali Z
Articles by Salehi P
Articles by Derakhshan-horeh M
Articles by Sadeghi E
Articles by Izaditabar A
Articles by Salehi M
Articles by Hosseinzadeh M

PubMed

Articles by Zakiye Nadeali
Articles by Peyman Salehi
Articles by Erfan Sadeghi
Articles by Amin Izaditabar
Articles by Mansoor Salehi
Articles by Majid Hosseinzadeh

Submit Paper
Online Submission System
CJMB ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center
Publication Information
Publisher
Aras Part Medical International Press Editors in Chief
Arash Khaki
Editor
Zafer Akan Deputy Editor
Javadi, Leila
Published Article Statistics