|The Effect of Magnesium Sulfate on Sperm Characteristics and Blood Hematology After Testicular Ischemia / Reperfusion (I/R) Injury in Rats|
|Saadat Moshkelani1, Ahmad Asghari, Gholamreza Abedi1, Alireza Jahandideh1, Pejman Mortazavi2|
|1Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Veterinary Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran
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Keywords : Magnesium sulfate, Testis, Ischemia/reperfusion, Rat
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Objective: The aim of present study was to investigate the effect of magnesium sulfate single intraperitoneal (i.p) administration on sperm characteristics on testicular ischemia-reperfusion (IR) injury in the male rats.
Materials and Methods: 30 adult rats were randomly divided into five groups: sham operations (group 1), I/R (group 2), I/R + 125 mg/kg MgSO4 (group 3), I/R + 250 mg/kg MgSO4 (group 4), I/R + 500 mg/kg MgSO4 (group 5). Testicular ischemia was achieved by 720° torsion of the left testis for 2 hrs. Then, detorsion was performed and reperfusion was induced. One hour after ischemia, three different doses (125, 250 and 500 mg/kg) of MgSO4 were administrated. The sperm count, motility, mobility and blood hematology were evaluated.
Results: there was a significant increase in sperm count, motility, mobility in treatment groups (MgSO4) compared to the sham group (P<0.05). Also, lymphocyte counts in the sham group compared to I/R group increased significantly (P<0.05).
Conclusion: What was depicted through this study implied that MgSO4 can improve sperm characteristics after testicular ischemia-reperfusion injury.
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