The Effect of Magnesium Sulfate on Sperm Characteristics and Blood Hematology After Testicular Ischemia-Reperfusion Injury in Rats

Saadat Moshkelani; Ahmad Asghari; Gholamreza Abedi; Alireza Jahandideh; Pejman Mortazavi

E-ISSN : 2148-9696

Crescent Journal of
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Original Article
The Effect of Magnesium Sulfate on Sperm Characteristics and Blood Hematology After Testicular Ischemia-Reperfusion Injury in Rats
Saadat Moshkelani¹, Ahmad Asghari¹, Gholamreza Abedi¹, Alireza Jahandideh¹, Pejman Mortazavi²
¹Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran ²Department of Veterinary Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran
CJMB 2020; 7: 91–95 Viewed : 5030 times Downloaded : 2403 times. Keywords : Magnesium sulfate, Testis, Ischemia-reperfusion, Rat
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Abstract

Objectives: The aim of this study was to investigate the effect of magnesium sulfate (MgSO₄) administered single intraperitoneally on sperm characteristics after testicular ischemia-reperfusion (IR) injury in the male rats. Materials and Methods: Thirty adult rats were randomly divided into 5 groups: sham operations (group 1), IR (group 2), IR + 125 mg/kg MgSO₄(group 3), IR + 250 mg/kg MgSO₄(group 4), and IR + 500 mg/kg MgSO₄(group 5). Testicular ischemia was achieved by 720 degrees torsion of the left testis for 2 hours. Then, detorsion was performed and reperfusion was induced. One hour after ischemia, three different doses of MgSO₄(125, 250, and 500 mg/kg) were administrated intraperitoneally. The sperm count, motility, mobility, and blood hematology were evaluated. Results: There was a signifcant increase in sperm count, motility, and mobility in groups treated with MgSO₄compared to the sham group (P<0.05). In addition, lymphocyte count in the sham group signifcantly increased compared to the IR group (P<0.05). Conclusions: Generally, this study demonstrated that MgSO4 can improve sperm characteristics after testicular IR injury.