|Effect of Nano-capsules Containing Risedronate on Calvaria Bone Formation In Rabbit: Radiography and Biochemical Investigation|
|Hesam Aldin Hoseinzadeh1, Ahmad Asghari1, Gholamreza Abedi1, Abolfazl Akbarzadeh2,3, Reza Sedaghat4|
|1Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Universal Scientific Education and Research Network (USERN), Tabriz, Iran
4Department of Anatomy and Pathology, Faculty of Medicine, Shahed University, Tehran, Iran.
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Keywords : Nano-capsules, Risedronate, Calvaria healing, Radiography, Rabbit
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Objective: The main purpose of the current study was to determine effect of nano-capsules containing Risedronate calvaria bone formation in rabbit.
Materials and Methods: 15 adult rabbits allocated into the study. Four holes were created in the calvarial bone. The holes 1-4 were filled as described below: The hole 1 was right unfilled and kept as control. The hole 2 was filled with nano bone. The hole 3 was filled using an autogenous bone. The hole 4 was filled with mixture of nano-capsules containing Risedronate. At 4, 8 and 12 weeks after surgery, blood samples obtained and red blood cell, white blood cell, hemoglobin, hematocrit, mean cell volume, mean cell HGB and platelets were determined. Then animals scarified and bone density determined using radiography images.
Results: Bone formation in nano Risedronate+autograft (0.31±0.03), autograft (0.25±0.02) while in nano Risedronate and control groups were 0.11±0.01 and 0.08±0.02, respectively (P<0.05). Significant differences observed on done density in nano Risedronate+autograft was 0.37±0.01 while in the autograft, nano Risedronate and control groups were 0.32±0.01, 0.14±0.01 and 0.09±0.02, respectively (P<0.05). Bone density after 12 weeks were 0.51±0.01, 0.36±0.02, 0.21±0.01 and 0.19±0.02 in nano Risedronate+autograft, nano Risedronate, autograft, and control groups, respectively (P<0.05). In the all stage of the study the nano Risedronate+autograft had better bone formation in comparison to the other groups (P<0.05). Different filling material into defects had no effect on blood hematology indexes (P>0.05).
Conclusion: These results suggested nano Risedronate+autograft has positive effects on bone formation on calvaria healing in rabbit.
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