|Investigation of The Association of C381T Polymorphism in Notch3 Gene with Cerebral Stroke Patients|
|Afsoon Ghoreishizadeh3, Seyed Mahmoud Tabatabaei1, Ashkan Adibi2, Saba Dastar3|
|1Department of Physiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2Department of Genetics, Tabriz Branch, Islamic Azad University, Tabriz, Iran
3Department of Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran
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Keywords : Cerebral stroke, C381T polymorphism, Notch3
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Objective: Cerebral stroke is a common multifactorial trait that does not follow Mendelian pattern of inheritance. The phenomenon of gene-gene or gene-environment interactions may be responsible for the multifactorial traits. Any mutation may be associated with silencing has been implicated in other disorders. This study has explored the association between Notch3polymorphisminteractions and stroke in Iranian-Azeri population in a case-control study.
Materials and methods: In this case-control study, C381T polymorphism of Notch3 gene evaluated among 65 patients with ischemic strokeand 65 individuals without any stroke as control group. Control samples recruited from five clinical centers during 2014-2015and PCR-SSCP and sequencing methods used to obtain the data
Results: In this study, the frequency of C and T alleles in the patients group is 85%, 15% and in control group were 94% and 6% respectively. The frequency of CC, CT and TT genotypes were 72%, 26% and 2% and in control groups were 88%, 12% and 0% respectively. Both control and patient groups had significant difference considering their both allele and genotype frequencies. The individuals with Notch3 C381T polymorphism had a significantly higher risk of thrombotic stroke (p value = 0.02, CI:0.128-0.256: 95%, OR:2.72).
Conclusion: Our results showed that combination of T allele of this gene conferred higher risk for cerebral stroke. The gene mutation-post-translation modification interaction may serve as a novel field for stroke research.
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