|The Association of C381T Polymorphism in Notch3 Gene With Cerebral Stroke|
|Afsoon Ghoreishizadeh1, Seyed Mahmoud Tabatabaei2, Ashkan Adibi3, Saba Dastar1|
|1Department of Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran
2Department of Physiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
3Department of Genetics, Tabriz Branch, Islamic Azad University, Tabriz, Iran
CJMB 2018; 5: 253–257
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Keywords : Cerebral stroke, C381T polymorphism, Notch3 gene
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Objectives: Cerebral stroke is a common multifactorial trait that does not follow Mendelian pattern of inheritance. The phenomena of gene-gene or gene-environment interactions may be responsible for the multifactorial traits. Any mutation may be associated with silencing implicated in other disorders. This case-control study explored the association between
Materials and Methods: In this case-control study, C381T polymorphism in Notch3 gene was evaluated among 65 patients with ischemic stroke and 65 individuals without any stroke as control group. The samples were recruited from 5 clinical centers during 2014-2015. PCR-SSCP and sequencing methods were used to obtain the data.
Results: In this study, the frequencies of C and T alleles in the patient group were 85% and 15%, and in the control group were 94% and 6%, respectively. The frequencies of CC, CT and TT genotypes were 72%, 26% and 2% in the patient group, and 88%, 12% and 0% in the control group, respectively. Both control and patient groups had signifcant difference considering their both allele and genotype frequencies. The individuals with C381T polymorphism in Notch3 gene were in a signifcantly higher risk of thrombotic stroke (P = 0.02, CI: 0.128-0.256: 95%, odds ratio [OR]: 2.72).
Conclusions: Our results showed that combination of T allele of this gene conferred higher risk for cerebral stroke. The interaction of gene mutation with post-translation modifcation may serve as a novel feld for stroke research.
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