|Non Alcoholic Fatty liver Disease Among High-Risk Individuals and its Predictive Factors in Health Insurance Employees of Tabriz, Iran|
|Saeed Jodi1, Azizeh Farshbafkhalili2, Reza Nikanfar3, Leila Javadi4|
|1East Azerbaijan Heaith Insurance Organization, Tabriz, Iran
2Physical Medicine and Rehabilitation Research Center, Midwifery Department, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Health Education and Promotion, Tabriz University of Medical Sciences, Tabriz, Iran
4Nutrition Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords : AST, ALT, Alcoholic ,Fatty liver Disease
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Objective: Non alcoholic fatty liver disease (NAFLD) has been known as the most frequent type of liver diseases, with an assessment occurrence of 20 to 30% in developed countries and 33.9% in Iran. In this study we aimed to evaluate the prevalence of fatty liver among high-risk individuals and its predictive factors.
Materials and methods: The analytic cross-sectional study was performed on 70 men and women, aged 32–62 years and BMI≥25 were divided into two groups: 1) The patient group (P=45) with positive results of fatty liver disease 2) The healthy group (n=25) An anthropometry assessment (weight and BMI), blood tests (AST, ALT, FBS, TC, and TG), and fatty liver grade were done.
Results: In our study the rate of NAFLD was 64 among 100 susceptible individuals (BMI≥25).We found significant differences in sex (P=0.020), weight (P<0.001), BMI (P=0.001), AST (P<0.001), ALT (P<0.001), and AST/ALT (P<0.025) between the groups. A direct association between Increase in BMI and NAFLD )P=0.001) was observed. In the study of relationship between fatty liver grade with BMI and biochemical factors, there were significant differences in mean BMI, weight, AST, ALT and AST/ALT between patients with NAFLD grade 1 and 3. But no significant changes were observed for FBS, TC and TG between patients with NAFLD grade 1, 2 and 3. Sex, BMI and AST were estimated as independent predictors of NAFLD. The risk of NAFLD increases by male sex (P=0.053), increment of BMI (P=0.002) and AST (P=0.002) in the study.
Conclusion: This study verifies the relationship between NAFLD with Obesity and liver aminotransferase has been repeatedly reported in NAFLD.
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