|Comparing the Effectiveness of Flaxseed and Fish Oils on Acute Ischemia-Reperfusion Injury in the Rat Kidney|
|Maryam Moghimian1, Seyed-Hosein Abtahi-Eivary2, Najme Jajarmy2, Mahdi Karimi Shahri3, Javad Adabi4, Majid Shokoohi5|
|1Department of Physiology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
2Department of Biochemistry, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
3Department of Pathology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
4Clinical Laboratory, 22 BahmanHaspital, Gonabad University of Medical Sciences, Gonabad, Iran
5Department of Anatomical Sciences, faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
6Student in nursing (BSc), Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran
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Keywords : renal ischemia-reperfusion, oxidative stress, fish oil, flaxseed oil
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Introduction:Polyunsaturated fatty acids (PUFAs) are useful in reducing deleterious effects of ischemia-reperfusion (IR). This study was designed to compare the effects of treatment with flaxseed oil, rich in linoleic acid and alpha-linolenic acid, and fish oil containing long PUFAs, eicosapentaenoic acid and docosahexaenoic acid, on IR injury in the rat kidney.
Methods:As an experimental study, 32 male Wistar rats were randomly divided into four groups, each 8 rats: Sham, ischemia-reperfusion (IR), flaxseed oil (FLO), and fish oil (FO). Correspondingly, experimental groups were administered saline and flaxseed or fish oil at doses of 0.4 g/kg, through gavage.
Results: Serum Cr and BUN levels, AST activity, and tissue MDA content increased in the IR group. Both fish and flaxseed oils decreased tissue MDA levels (P< 0.05 vs. IR), but could not lead to a significant reduction in the levels of the renal markers. Histological damages increased following IR were also markedly reduced by these two oils.
Conclusion: Flaxseed oil as well as fish oil may provide protection against IR-induced renal injury and oxidative stress and these effects were not significant between the two supplementations.