|Antioxidant Properties of Allium Cepa (onion) Against Permethrin-induced Toxicity on LHCGR and SF1 Genes in Male Rats|
|Asghar Rajabzadeh1, Amir Afshin Khaki2, Arash Khaki3|
|1Department of Anatomical science, Tabriz Medical faculty, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Anatomical Sciences, Tabriz University of Medical Sciences and National Public Health Management Center (NPMC), Tabriz, Iran
3Women's Reproductive Health Research Center, Tabriz University of Medical Sciences
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Keywords : Allium Cepa, Permethrin, Male rat, LHCGR, SF1
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Objectives: The use of pyrethroids due to availability and less toxic to mammals is wide spread. Permethrin is type I pyrethroid that usually used in agriculture industry and homes. High dose of these chemicals have destructive effects on biological systems mainly in spermatogenesis cycle. The aim of this study was to investigate the effects of permethrin on key genes SF1 and LHCGR as well as hormonal levels (FSH and LH) of testis. A natural antioxidant (onion) was used to investigate its positive impact on the negative effects of permethrin.
Material and Methods: Adult male rats were divided into 5 groups. Group 1 was considered as control group. Group 2received DMSO and Group 3 received PER daily (35mg/kg). Group 4 in addition to permethrin at the same dose also received 3 ml onion juice. Group 5 only received 3 ml onion juice. After two months, the gene expression levels were examined by using Real Time RT-PCR. Testes were processed for sexual hormones level. Results: Results show that exposure to permethrin represent a significant reduction in expression of genes and hormonal levels. Onion juice has a moderate function in the expression of genes and prevented from decrease in serum levels of FSH and LH compared to normal condition.
Conclusions: This hypothesis can be stated firmly that toxicity effects of permethrin can reduce male fertility. Therefore, by consumption natural antioxidants like onion can be depressed these damages.
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